The 2021–22 AEFA Champions' League will be the eleventh edition of the AEFA Champions' League, which will begin in October 2021 with the group stage and will culminate with the final in May 2022. Thirty-two teams will participate in the competition from fifteen nations.
Allocation of clubs
The number of berths awarded to each AEFA member depends on that nation's FMF club coefficient. The highest-ranked leagues will receive up to three berths each, whilst lower ranked nations would receive fewer places. Furthermore, nations that do not organise their own domestic leagues, whose clubs play in the domestic league of another member, will only be allocated one place.