Designed Genetic Coding
This is an article that deals with the concept of DNA Sequencing which is a topic in the realm of Genetic Science. This article will discuss, explain and recount the exact sequencing process utilized in the neonatal process from initial conception to the point of delivery of a child including potential side effects and the point of current research and application within Sayaffallah.
History
RNA strand sequencing
In 1856 Leopold Ziegeiter, a prominent researcher and scientist in Sayaffallah discovered a prominent strand of RNA within the sequence of dioxyribosenucleic acid (DNA) that could be manipulated for small synthetic variations in its initial strand layers. By changing the quantity of adenineand cytosine within the nucleotide of DNA it was found that a 12 rather than 5 methyl cytosine strand was replicated and modified (12mC) because of the significant increase it was determined through the trial phase that it increased and enhanced the resiliency of the DNA strand from mutation in the later phases of conception and fetal development.
Ziegeiter was ecstatic at the discovery of this strand however the government at the time was less ecstatic and ordered Zeigeiter on pain of death to keep his discovery secret and to continue to develop new innovations and breakthroughs for the good of the country. The data was thus internally kept as a state secret and only shared on a need to know basis with scientists who were also researching the same topic and utilizing the exact same DNA strands that Ziegeiter was using in his experimental stages.
Genome mapping
1862 brought new developments from the laboratory of Ziegeiter and his staff of now nearly 200 scientists sworn to secrecy and kept in luxurious surroundings of a mountain retreat known as Zatergast, the new developents were a complete mapping of the human genome specifically all of its strands and its sequencing as well as earlier cross referencing with the development of disorders and disease from the parents chromosomal exchanges during fertilization of the egg immediately after intercourse. The mapping of the genome was a huge accomplishment and allowed researchers to see the entire human genome in vivid detail and of course able to see which patterns and sequences led to which conditions and disorders and which ones accentuated the human individual either by increasing appearance or intellectual curiosity or athletic ability.
Researchers found that those in Sayaffallah who at the time had a higher disposition to attaining a disorder or disease or condition later in life were born with incredible abilities ranging from intellectual capacity to attractiveness. It was determined that these abilities were a survival mechanism occurring naturally in the body to help it survive future mutations of the genetic code. Researchers at this time came up with the Genome Survival Theorem which in short hypothesized that the genome was always constantly and rapidly changing and mutating over time as the body degraded and went beyond its peak abilities thus requiring a survival mechanism of either intellectual capacity, attractiveness or athletic ability as means of coping. Scientists observed that those who early on had a higher ability in these three key areas later contracted debilitating disease, disorder or condition that limited their overall functionality yet these abilities provided them with significant quality of life.
Fetal stage discovery
From 1875-1902 a study was conducted with the voluntary participation of 6550 parents and their children to monitor development both physical, social and academic of newborns throughout their span of life into adulthood. These children were taken to the Zatergast Resort in the mountains along with their parents and housed there for much of their childhood with frequent trips to the seaside and organized social outings and eventual transition into regular public school settings by age 13. The children were monitored with frequent blood examinations and genetic analysis to determine the progression of their particular assigned genetic traits from fetal stage through adulthood.
The discovery made by scientists was an earth shattering one on December 2, 1902 when their research revealed that the genetic growth of these participants ended at the point of birth with their particular genetic strand being locked in place with whatever changes would occur later in life and whatever conditions would develop already set in place. This meant that the Genome Survival Theorem was disproved and no longer applicable but it also meant that scientists could now focus exclusively on the point of development of the DNA strand during fetal stage and determine whether or not replicating, manipulating and changing the DNA strands during this process and prior to conception would result in significant changes later on in life.
A new study was commissioned and from 1903-1923 a new selection of 6500 parents and children were put through the same process except this time 500 of those participants were the reserve case in which nothing was done to alter the genetic makeup and thus became the marker by which all results would be measured. Researchers on the 6000 other cases altered the genetic sequencing during the point of conception from fertilization to a week before delivery and waited to see what result would take place among the children. The results achieved at the end in 1923 were phenomenal. The children who were given altered DNA restructuring and re-sequencing with their specific condition or future disease/disorder targeted were found to have those completely eliminated from their genetic code and instead their natural survival mechanisms were enhanced and heightened making them into what society identified as an ideal citizen. Of these children over 4 became future Prime Ministers of Sayaffallah and to this day the identity of those four remains a secret to the general public as the data has never been fully disclosed except to show the findings.
Fragmented DNA technique
After the discovery of Fetal Stage Genetic Closing (FSGC) ,as it would later become known, scientists and researchers wanted to find a way in which blood work could quickly identify and establish existing disorder or disease or conditions within the DNA strands of those individuals at full maturation and likely to become pregnant as well as the strands of their spouse or partner so as to determine the point at which an individual would be likely to contract the condition, disease or disorder and to determine which specific strand contained those mutations allowing for changes later in life. To achieve this Gillian Abernas proposed taking a fragment of DNA and stripping it to determine its exact sequencing steps from start to finish and then examining it in a full illustrated sequence to determine the point at which microscopic mutations occurred.
The process was successful in determining the exact point at which mutations occurred however its laborious nature required significant manpower to accomplish and furthermore required a span of months to fully complete. Attempts at automation were initiated specifically to take a blood analysis and extricate DNA sample from the hemoglobin and use it to determine the exact point at which mutation could be observed through microscopic analysis however these attempts at automation proved to also be too time consuming. On January 5, 1948 researchers in B Group made an important discovery that if DNA fragments were stripped and analyzed using a chemical solution it could speed up the process of reviewing the genetic sequencing without it taking months to accomplish. The discovery effectively reduced the time of processing from 6-10 months down to a period of 1-2 days allowing researchers to comb through vast amounts of data to compile what would become an exhaustive guidebook to blood and tissue DNA sampling and sequencing allowing researchers to begin the next phase of research in identifying commonalities in DNA in order to begin eliminating specific strands that contributed to disease, disorder or malignant conditions.
Elimination of mutation DNA strands
On October 14, 1973 the process of eliminating DNA Strands with known links to mutation causing disease, disorder or condition later in life was finalized with a research study involving over 3,650,200 individuals over a 30 year period was concluded. The analysis was made public including prior research on genetics within Sayaffallah and the process of designed genetic coding was approved as medical procedure essential making it a free procedure available as a basic human right to expectant parents during the birth process in which tissue samples and DNA sequencing would be conducted to determine strands and then mutation replacement and re-sequencing would take place to strengthen positive cycles and strands of DNA while completely eliminating negative ones that would cause complications later in life.
The approval of this procedure caused significant buzz throughout Sayaffallah specifically in the scientific and medical communities and its popularity increased over the years as it became more refined. By 1995 it was estimated that nearly 99% of negative mutations within the DNA strand had been eliminated among those living Sayaffallah and those given access to the treatment from abroad. Now the treatment is commonplace within Sayaffallah and is constantly being improved upon with other applications for cellular growth particularly later in life for traumatic injuries.
Procedure
Current Designed Genetic Coding (DGC) procedure
Presently Designed Genetic Coding is the process by which DNA strands are coded, analyzed,sequenced and then re-sequenced to emphasize positive traits non detrimental to growth, development and quality of life. Exact sequencing can be done through the stripping of the DNA down to its most basic RNA sequencing and then introducing the chemical solution composed of liquid aminos to the DNA strand which allows it to be sped up under microscope in which mutations can be observed as non linear during cellular meiosis phase. By analyzing within meiosis as opposed to other phases of cellular development the exact detailing can be seen and the mutations stand out more because of their inability to fit the preset pattern of other marker strands of DNA sequencing. Within the typical blood cell more than sixty five million individual separate strands of DNA can be observed through microscope with many of these being identical and thus supporting a larger growth of a particular trait or characteristic later on, when a strand is outside the normal frame of known DNA it can be viewed as a mutation.
Because mutations have been comprehensively catalogued and put into an electronic system they can be scanned and then run through the system and identified quickly. Not all mutations lead to negative consequences later in development. Some mutations are a strengthening of known survival metrics within the DNA strand and can lead to a deepening or a reinforcing of those characteristics during the normal childhood development process. Likewise DNA strands have been completely catalogued in a database as well and many individuals have similar strands as other individuals although on a nanoscopic level these strands cannot be completely identical as each strand has its own minutia level differences making that one individual unique in their own way. After a mutation is observed and identified the system will indicate the specific strand replication and re-synthesizing needed to accomplish successful elimination of the mutation. Once the re-sequencing is complete the DNA sequence is monitored through 4 subsequent visits over a 4 week period after the first visit. The first visit typically occurs a month into the pregnancy and the 4 subsequent visits monitor the re-sequencing for any retrograde mutations developing after the re-sequencing takes place.
If a mutation develops after re-sequencing a more aggressive form of sequencing is put in place in which DNA stands that are positive are reinforced and strengthened with replication of those strands at the nano level typically through replication of positive RNA and Eukaryotas found in the blood stream. Through successful replication at an aggressive stage individuals will often see their positive physical/intellectual/athletic traits develop at a faster and a higher level than before. Alternatively those who are desiring tailored DGC will often receive a more aggressive cycle along with modified strands to accentuate desired characteristics.
Designer DGC
Designer DGC is a common nickname for Aggressive Designed Genetic Coding (ADGC) which allows parents to amplify positive traits found within the DNA sequencing so as to increase the potential for athletic ability, intellectual capacity and physical capacity later in the development process. Typically this can be accomplished through aggressive replication of positive patterns in the strand sequence and introduction of a large scope of proteins. Typically known strands of traits that are formative in the intellectual/athletic/physical realms are introduced as well giving the individual the ability to dramatically increase their working abilities later in life. When these strands are introduced it has to be carefully monitored so that it does not create a permeated mutation that can be difficult to remove. On an ADGC cycle there are 12 required visits total starting a week after a pregnancy result is determined after an initial pregnancy screening. The first visit involves introducing specific embryonic level strands that will begin the process of interacting. During the first week the woman is typically hospitalized for observation purposes with new blood tests taken several times a day each day along with a transfusion of essential nutrients and embryonic strands throughout the day during the week of observation. At the end of the week a complete assessment is conducted including a total review of embryonic DNA strands to determine the progress made during the week. After this is completed the next visit is a week later and marks the beginning of an aggressive transfusion process to strengthen the woman during pregnancy and on an embryonic level to strengthen the child during the process of development in the womb.
ADGC is becoming more and more popular in Sayaffallah particularly among younger mothers who desire to see their child reach their full potential. Complications however are not unheard of particularly during the transfusion process but no complication has ever resulted in the death of the mother or the developing child. Typically complications come from a mother weakening during the transfusion process and needing to be admitted for another week of observation during which time essential nutrients and proteins are introduced into the bloodstream greatly strengthening the chances of the pregnancy surviving and becoming successful in the long-term.
Ethics and concerns
Database privacy
The database for mutations and DNA strand identification has been compiled with the partial and complete DNA of over 6.2 million Sayaffallans over a 120 year period allowing a comprehensive picture of known and emerging conditions to be at the fingertips of physicians. The database however is designed with privacy in mind with no names being linked to the strands of DNA or the DNA mutations in the database and with each entry being linked simply to a number which is linked to a paper hard-copy file with pertinent medical information of the patient whose DNA was contributed. This in turn is a hard copy file with no name on it but with the medical history of the individual, if a name is needed the individual or their living relatives must sign off on it. In order to obtain the name of the individual or living relatives an additional second number is provided which leads to a card catalogue database in another locked away medical archive building which is guarded around the clock. Those guarding the archive have no idea what the number on the card in the catalogue they are guarding is for other than it is a sensitive number. The number in the card catalogue links to the number on the file folder in the reserve archive where the medical histories are stored.
Furthermore individuals freely donate their DNA information to this database either on their own request and initiative during life for a payment of the equivalent of $200,000 or upon death for the same equivalent payment. Those who participate in DGC procedures have their DNA discarded upon completion unless they request to be a part of the database system in which case they are required to undergo medical testing to ensure that their DNA is capable of being stored for a long period of time within the database and remain current for usage.
Designer DNA human cloning
A long standing debate exists in Sayaffallah in regards to human cloning and the "designer DNA" process otherwise known as ADGC. There are some who feel that tampering with DNA to increase advantage in life is an inappropriate exercise that demeans the value of human life. Ethicists have long supported greater controls to ensure that inappropriate use of DNA does not occur, and to this day in response to that pressure all DNA procedures are logged by alphanumeric number in the medical records of the individual and are done according to strict standards to ensure that the individual is not given mutation or unfair result.
Research state secret
Until 2015 the research of Designed Genetic Coding including its entire history remained a state secret and only those physicians who passed extensive review and applied for security clearance were given access to the database and the ability to conduct procedures. That all changed following a movement started by a group of medical students which spread across the country starting in 2005 when medical students were denied the ability to use the database of DNA research for clinicals. Medical students refused to go to classes and soon over 2.6 million students rallied for a 2 week period in the streets of Sayaffallah largely in the capital of Bellissimomare. The government in turned ordered the students to report back to their classes the following Monday or the Ministry of Education would require their schools both private and public to forfeit their spots in the program and give the spots to those on a national waiting list of students.
The medical students took a brave stand and refused and they were replaced by new students, this led to a national outrage and the demand that the students be taken back into the schools. The government refused and the Sultan intervened in a rare move describing the students as "unmotivated and lazy and individuals who should spend as much energy as they do protesting in the classroom preparing to be doctors". The bulk of these students who were replaced would change their focus and enter into different schools for a variety of different disciplines in the medical field with many opting to become nurses and than later go to medical school to become doctors. This decision by the government only intensified desire for the research to enter the public domain and on July 1, 2015 the parliament formally passed a law and invited all the prior medical students to come to the parliament as it was signed by the Sultan requiring the research to be made public. However the law had significant caveats specifically requiring patient information to remain closely guarded and physicians to pass rigorous testing to be granted access to the database itself and perform the genetic procedures.
